GRK2 Antibodies

AND GRK2 ELISA kits, GRK2 Proteins

Many biological assays use antibodies to detect GRK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRK2 antibodies...

We validate the specificity of these antibodies to GRK2 by testing them on tissues known to express GRK2 positively and negatively. Browse below to find the GRK2 antibody that suites your experiment. We have 11 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GRK2 Infographic by Boster Bio

All GRK2 Products

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Product

Figures

Specificity

Applications

Price

Anti-GRK2/GRK2 Antibody Picoband®

1 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A01473-1
100 μg/vial

GRK2 Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$480
Cat # EKC1252
1 kit, containing one 96-well plate and all necessary reagents

ARBK1 Colorimetric Cell-Based ELISA

Human, Mouse, Rat

ELISA

$480
Cat # EKC1696
1 kit, containing one 96-well plate and all necessary reagents

GRK2 (Phospho-Ser29) Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$540
Cat # EKC2073
1 kit, containing two 96-well plates and all necessary reagents

GRK2 (Phospho-Ser685) Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$540
Cat # EKC2602
1 kit, containing two 96-well plates and all necessary reagents

Anti-GRK2 (T23) Antibody

Human, Mouse, Rat

IHC

$405
Cat # A32388T23
100ul

Anti-GRK2 (Phospho-Tyr86) Antibody

Human, Mouse, Rat

IHC, WB

$380
Cat # A32388Y86
100ul

Anti-Phospho-GRK 2 (S685) Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A32388S685
100ul

Anti-Phospho-GRK 2 (S29) Antibody

Human, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A32388S29
100ul

Anti-GRK2 Antibody Picoband®

Human, Monkey, Mouse, Rat

Flow Cytometry, IF, ICC, WB

$370
Cat # A32388-1
100 μg/vial

GRK2 (NM_001619) Human Over-expression Lysate

Human

$628
Cat # LS000156
100 µg

GRK2 Overview

Facts about Beta-adrenergic receptor kinase 1.

GRK2 3D structure. Source: alphafold

Beta-adrenergic receptor kinase 1 (GRK2)

Specifically phosphorylates the agonist-occupied kind of the beta-adrenergic and closely related receptors, probably causing a desensitization of those. Key regulator of LPAR1 signaling.

Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378).

Gene Information

Human
Gene Name:	GRK2
Uniprot:	P25098
Entrez:	156

Family

Belongs to:

protein kinase superfamily

Alternative Names

ADRBK1; adrenergic, beta, receptor kinase 1; BARK; BARK1; BARK1beta-ARK-1; Beta-ARK1; Beta-ARK-1; EC 2.7.11; EC 2.7.11.15; FLJ16718; G-protein coupled receptor kinase 2; GRK2; GRK2beta-adrenergic receptor kinase 1

Molecular Weight

Mass (kDA):
79.574 kDA

Genomic Context


Human

Location:	11q13.2
Sequence:	11; NC_000011.10 (67266420..67286556)

Tissue Specificity

Expressed in peripheral blood leukocytes.

Subcellular Localizations

Cytoplasm. Cell membrane.

Diseases

Heart Failure
Hypertensive Disease
Inflammation
Infarction
Myocardial Infarction
Hypertrophy
Pertussis
Ischemia
Neoplasms
Diabetes Mellitus
Pain
Cardiac Failure Chronic
Nervousness

Cardiovascular Diseases
Malignant Neoplasms
Hyperalgesia
Myocardial Ischemia
Insulin Resistance
Hyperplasia
Diabetes Mellitus, Non-insulin-dependent

Interacting Proteins

FPR1
GIT1
GRK3
MDM2
NFKBIA

PTCH1
UBC

Pathways

Receptor Internalization
Pathogenesis
Localization
Endocytosis
Chemotaxis
Transport
Aging
Cell Proliferation
Secretion
Vasoconstriction
Bioluminescence
Cell Migration
Excretion

Sensitization
Vasodilation
Cell Growth
Receptor Recycling
Hyperphosphorylation
Proteolysis
Tubulin Deacetylation

PTMs

Phosphorylation
Dephosphorylation
Cleavage
Nitrosylation
Reduction

Glycosylation
Deacetylation
Acetylation
Ubiquitination
Demethylation

Ribosylation

Research Areas

Cancer
Cellular Markers
Mitochondrial Markers
Neuroscience
Protein Kinase

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRK2

References

PMID: 2037065 by Benovic J.L., et al. cDNA cloning and chromosomal localization of the human beta- adrenergic receptor kinase.

PMID: 1339451 by Chuang T.T., et al. High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation.